Biocera coating for TITANIUM

Characterisation by the University of Manchester, supported by Innovate UK grant 61320 – 435222.

• Optimised topography and morphology, three-layered structure:

• Rough outer layer (1) beneficial for osseointegration and drug release.
• Compact intermediate layer (2), responsible for scratch and wear resistance.
• Dense barrier interface layer (3) prevents release of metal ions from Ti (4) alloy.

• Natural bone-like colour: reflectance  30% - 42% vs etched Ti  26% - 30%.
• Higher corrosion resistance than bare Ti.
• Robust coatings material demonstrated high scratch resistance.
• Unique coating composition comprising:

1. Nanocrystalline oxide of zirconium ZrO2  and titanium TiO2.
2. ZrO2 is present in two crystalline phases: monoclinic and orthorhombic.
3. KZr2(PO4)3 kosnarite - polymetallic phosphate, a signature material.

• Invitro tests demonstrated good apatite induction, cell proliferation and differentiation.
• In vivo tests proved significantly higher osseointegration of coated implants vs uncoated. Bone implant contact (BIC) for coated implants was 65% higher than for uncoated Ti.